Title:
VITAMIN D3 DERIVATIVE
Document Type and Number:
Japanese Patent JPS6253960
Kind Code:
A
Abstract:
NEW MATERIAL:A 24,24-difluoro-26,27-dimethylvitamin D3 derivative expressed by formula I (X is H or OH).
EXAMPLE: 3β-24ζ-Dihydroxy-24-tris(methylthio)methylchol-5-ene.
USE: A medicine, having osteogenetic action and useful for treating and preventing various diseases caused by abnormality and disorder of calcium regulation or calcium absorption, e.g. calcium dysbolism or osteoporosis, etc.
PREPARATION: A compound expressed by formula II (Y1 is H or acyloxy; Z1 is acyl) is fluorinated and ethylated. A double bond is then introduced thereinto to give a compound expressed by formula III, which is then irradiated with ultraviolet rays at -20W+120°C for 1W2hr using a mercury lamp, etc., to afford the aimed compound expressed by formula I.
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Inventors:
IKEGAWA NOBUO
Application Number:
JP12415786A
Publication Date:
March 09, 1987
Filing Date:
May 29, 1986
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61P3/02; A61P3/14; C07C67/00; A61K31/59; C07C401/00; C07J9/00; C07J31/00; (IPC1-7): A61K31/59; C07C172/00
Attorney, Agent or Firm:
Kitagawa Fuzo