Title:
WK-5344A物質及びWK-5344B物質並びにそれらの製造法
Document Type and Number:
Japanese Patent JP4351395
Kind Code:
B2
Abstract:
The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein, WK-5344A substance and WK-5344B substance, and process for production thereof. A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human.
Inventors:
Satoshi Omura
Hiroshi Donada
Yoko Takahashi
Hiroshi Donada
Yoko Takahashi
Application Number:
JP2000603413A
Publication Date:
October 28, 2009
Filing Date:
March 08, 1999
Export Citation:
Assignee:
Kitasato Institute
International Classes:
C12P13/00; C07F15/02; C12N1/20; C12P9/00; C12R1/465
Other References:
長谷川武治 編,微生物の分類と同定,株式会社学会出版センター,1975年 6月20日,pp.189-192
J. Antibiot.,1998年 7月,Vol.51, No.7,pp.624-628
供田洋 他,糸状菌の生産するFO-6651物質のコレステリルエステル転送蛋白質阻害活性,日本薬学会年会要旨集,1998年 3月,Vol.118, No.3,p.51
田畠典子 他,ピリピロペン誘導体によるコレステリルエステル転送蛋白質阻害活性,日本薬学会年会要旨集,1998年 3月,Vol.118, No.2,p.155
Nature,Vol.224, No.5219,pp.589-591
J. Antibiot.,1998年 7月,Vol.51, No.7,pp.624-628
供田洋 他,糸状菌の生産するFO-6651物質のコレステリルエステル転送蛋白質阻害活性,日本薬学会年会要旨集,1998年 3月,Vol.118, No.3,p.51
田畠典子 他,ピリピロペン誘導体によるコレステリルエステル転送蛋白質阻害活性,日本薬学会年会要旨集,1998年 3月,Vol.118, No.2,p.155
Nature,Vol.224, No.5219,pp.589-591
Attorney, Agent or Firm:
Kazunori Kobayashi