Title:
WATER-SOLUBLE PHARMACEUTICAL COMPOSITION IN THE STATE OF IONIC COMPLEX AND ITS USE
Document Type and Number:
Japanese Patent JP3664373
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a pharmaceutically effective polypeptide composition capable of enhancing the activity of the polypeptide contained in the composition.
SOLUTION: This water-soluble composition is such one as to contain an ionic pharmaceutically effective polypeptide complex selected from the group consisting of hedgehog proteins, osteogenic factors, growth factors, erythropoietin, thrombopoietin, G-CSF, interleukins and interferons. Furthermore, the composition contains an amphipathic compound. The polypeptide and the amphipathic compound form an ionic complex. The formation of the complex does not enhance the solubility of the polypeptide and is suitable for the enhancement of the activity of the polypeptide and/or the prolonged release of the polypeptide.
Inventors:
Apollon Papadimitrio
Application Number:
JP24801399A
Publication Date:
June 22, 2005
Filing Date:
September 01, 1999
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K9/00; A61K9/08; A61K9/107; A61K38/02; A61K38/04; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/20; A61K38/21; A61K38/22; A61K38/36; A61K45/00; A61K47/12; A61K47/28; A61K47/48; A61P43/00; C07K7/00; A61K; (IPC1-7): A61K38/00; A61K9/107; A61K38/21; A61K38/22; A61K45/00; A61P43/00
Domestic Patent References:
| JP2096533A | ||||
| JP4026630A | ||||
| JP3145432A | ||||
| JP62207226A | ||||
| JP62089627A | ||||
| JP61500790A |
Foreign References:
| WO1996036352A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto