Title:
INTERMEDIATE FOR PRODUCING ANTIBIOTIC MI43-37F11
Document Type and Number:
Japanese Patent JP3142273
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound useful as an intermediate for producing a specific carcinostatic antibiotic.
SOLUTION: A compound of formula I (R2, R3 are each H or a lower alkyl; R4 is a lower alkyl), for example, 3-formyloxymethyl-6-methoxy-8-hydroxy-1H-2- benzopyran-1-one. The compound of formula I is obtained, for example, by treating a compound of formula II (R1 is H or a lower alkyl; L is an eliminable group) (for example, 3-benzyloxymethyl-6,8-dimethoxy-1H-2-benzopyran-1-one) with a Lewis acid such as BBr3 and subsequently reacting the obtained compound with a compound of the formula: R3-COOX (X is H, an alkali metal or the like) (for example, sodium formate) in a solvent such as dimethylformamide preferably at -5 to 50°C for 1-24 hr. The compound formula I is subjected to a hydrolysis treatment to give a carcinostatic biotic MI43-37F11.
Inventors:
Takeo Yoshioka
Ryoichi Miyata
Hiroshi Tone
Rokuro Okamoto
Hiroyuki Kumagai
Masaaki Ishizuka
Tomio Takeuchi
Ryoichi Miyata
Hiroshi Tone
Rokuro Okamoto
Hiroyuki Kumagai
Masaaki Ishizuka
Tomio Takeuchi
Application Number:
JP31216199A
Publication Date:
March 07, 2001
Filing Date:
August 31, 1990
Export Citation:
Assignee:
Mercian Corporation
International Classes:
C12P17/06; A61K31/365; A61K31/366; A61P35/00; C07D311/76; C12R1/465; (IPC1-7): C07D311/76
Domestic Patent References:
| JP32177A |
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)