Title:
植物、動物、およびヒトのワクチンとして並びに免疫療法に有用な抗体の免疫優性エピトープの弱化
Document Type and Number:
Japanese Patent JP3851938
Kind Code:
B2
Abstract:
The present invention provides a vaccine that can be administered to a mammal to cause immunoprotection in the mammal against a pathogenic organism that has an immunodominant epitope. The vaccine includes a modified form of the antigen in which the immunodominant epitope is located. In this modified form, the immunodominant epitope is immunodampened by any of a number of techniques. Examples of immunodampening techniques include addition of N-linked glycosylation sites, change of the net charge on the epitope, and substitution with a tolerated sequence. The vaccine also includes a pharmacologically acceptable carrier.
Inventors:
Gary, Robert Earl.
Nara, Peter El.
Gout Summit, Jap
Nara, Peter El.
Gout Summit, Jap
Application Number:
JP50766695A
Publication Date:
November 29, 2006
Filing Date:
August 19, 1994
Export Citation:
Assignee:
The Government of the United States of America, Represented by the Secretary, Department of Health and Human Services
International Classes:
A61K39/21; C12N15/09; A61K39/00; A61P31/12; C07K14/11; C07K14/16; C12N5/10; C12N15/44; C12N15/48; C12P21/02; C12R1/91; C12R1/92
Domestic Patent References:
| JP9500614A |
Other References:
Anders Bolmstedt et al. , The Journal of General Virology, 1992年,Vol.73, Part12, p.3099-3105
Sigvard Olofsson et al., Vaccines93 Modern approaches to new vaccines including prevention of AIDS, Harold S.Ginsberg et al., 1993年,p.183-187
Sigvard Olofsson et al., Vaccines93 Modern approaches to new vaccines including prevention of AIDS, Harold S.Ginsberg et al., 1993年,p.183-187
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto
Hiroshi Fukuda
Kato Kazunori
Katsuichi Nishimoto
Hiroshi Fukuda