PURPOSE: To provide a new compound having excellent antimycotic and antiprotozoan activity, also high in safety, thus useful for the therapies or prevention of various kinds of diseases derived from protozoa and true fungi such as carinii pneumonia.
CONSTITUTION: The objective WF11243 substance (or its salt) of the formula. Its hydrochloride has the following characteristics: (1) appearance: white powder; (2) melting point: 182-187°C; (3) molecular formula: C71H116N14O23.HCl.8H2O; (4) elemental analysis (calculated) :C:49.74, H:7.82, N:11.44; (5) elemental analysis (observed) :C:49.65, H:7.72, N:11.4; (6) solubility: readily soluble in methanol or water, poorly soluble in acetone, insoluble in hexane; (7) color reaction: positive for ninhydrin reaction, etc., negative for Ehrlich reaction, etc. The present compound can be obtained by culture of WF11243 substance-productive bacteria [e.g. No.11243 strain (FERM BP-3373) as novel microorganisms]. It is recommended that the culture be made aerobically at 14-36°C.
TAKASE SHIGEHIRO
YAMASHITA MICHIO
NAKANISHI TOMOKO
HASHIMOTO MASAHARU
OKUHARA MASAKUNI
