Title:
Gタンパク質共役受容体のモジュレーターを同定するための、広く適用できる方法
Document Type and Number:
Japanese Patent JP4991081
Kind Code:
B2
Abstract:
Identifying (M1) compounds (A) that modify, in an organism, the activity of at least one signal transduction pathway that depends on a G protein coupled receptor (GPCR). Cells that contain at least one GPCR-dependent pathway and at least one G protein are treated with test compounds and the qualitative and quantitative effect of the compound on the pathway is determined from a measurement signal that depends on the pathway. Independent claims are also included for the following: (1) (A) identified by (M1); (2) polynucleotides (I) that encode a polypeptide with G protein properties; (3) host cells containing (I) ; (4) method for producing cells containing (I); and (5) proteins (II) having sequences, reproduced, of 359 amino acids (aa) (S2), 353 aa (S4), 353 aa (S6) and 374 aa (S10).
Inventors:
Affi Cos Tennis
Application Number:
JP2002509518A
Publication Date:
August 01, 2012
Filing Date:
July 05, 2001
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C12N15/09; C12Q1/02; C07H21/00; C07K14/435; C07K14/47; C07K14/705; C12N1/19; C12N5/10; C12N5/16; C12N5/22; C12N15/12; C12N15/63; C12N15/66; C12N15/74; C12N15/79; C12P21/00; C12P21/02; C12P21/08; C12Q1/00; C12Q1/68; G01N33/50; G01N33/53; G01N33/567; G01N33/68; C07K; C12Q
Foreign References:
| WO1999005177A1 | ||||
| WO1997048820A1 |
Other References:
Anal.Biochem.,1999年,Vol.270,p.242-248
JBC,1997年,Vol.272,p.19107-19110
CONKLIN B.R.,CARBOXYL-TERMINAL MUTATIONS OF GQ ALPHA AND GS ALPHA THAT ALTER THE FIDELITY OF RECEPTOR ACTIVATION,MOLECULAR PHARMACOLOGY,1996年10月 1日,V50N4,P885-890
JBC,1997年,Vol.272,p.19107-19110
CONKLIN B.R.,CARBOXYL-TERMINAL MUTATIONS OF GQ ALPHA AND GS ALPHA THAT ALTER THE FIDELITY OF RECEPTOR ACTIVATION,MOLECULAR PHARMACOLOGY,1996年10月 1日,V50N4,P885-890
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Chika Takagi
Kosuke Nishimura
Noriyuki Takebayashi
Chika Takagi
Kosuke Nishimura