Title:
XANTHINE DERIVATIVE, PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JP2012121908
Kind Code:
A
Abstract:
To provide new dipeptidylpeptidase IV activity inhibitors.
The xanthine derivatives are substituted xanthines expressed by general formula (I) [wherein, R1 to R4 are each defined as in claim 1], their tautomers, stereoisomers, mixtures, prodrugs and salts (they show a valuable pharmaceutical property, especially, an inhibitory effect on the enzymatic activity of dipeptidylpeptidase IV).
Inventors:
HIMMELSBACH FRANK
MARK MICHAEL
ECKHARDT MATTHIAS
LANGKOPF ELKE
MAIER ROLAND
LOTZ RALF
MARK MICHAEL
ECKHARDT MATTHIAS
LANGKOPF ELKE
MAIER ROLAND
LOTZ RALF
Application Number:
JP2012045656A
Publication Date:
June 28, 2012
Filing Date:
March 01, 2012
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA
International Classes:
C07D473/06; A61K31/522; A61K31/55; A61K31/551; A61P3/04; A61P3/10; A61P5/00; A61P19/02; A61P19/10; A61P37/02; A61P37/06; C07D473/04; C07D473/08; C07D473/10; C07D473/12; C07B61/00
Domestic Patent References:
| JPS374895B1 | ||||
| JP2004502690A | 2004-01-29 | |||
| JP4395304B2 | 2010-01-06 |
Other References:
JPN7013004245; ＣＹＧＡＮＫＩＥＷＩＣＺ， Ａ． ｅｔ ａｌ: 'Ｐｉｐｅｒａｚｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｄｉｍｅｔｈｙｌｘａｎｔｈｉｎｅｓ． Ｖ． Ｐｒｅｐａｒａｔｉｏｎ ａｎｄ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ８-ｐｉｐｅｒａｚｉｎｏ- ａｎｄ １-beta' Ｒｏｍｕａｌｄ Ａｃｔａ Ｐｏｌｏｎｉａｅ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｖｏｌ．３４， Ｎｏ．６, 1977, ｐ．６０７-６１２
JPN6007001193; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （９）, 1999, ２４１９-２４２８
JPN6007001193; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （９）, 1999, ２４１９-２４２８
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Takaki Nishijima
Atsushi Hakoda
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