An activation method of a helper T-lymph cell

Japanese Patent JP6134139

B2

The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to any MHC class II molecule of an HLA-DRB1*0101 molecule, an HLA-DRB1*0401 molecule, an HLA-DRB1*0403 molecule, an HLA-DRB1*0406 molecule, an HLA-DRB1*0803 molecule, an HLA-DRB1*0901 molecule, an HLA-DRB1*1101 molecule, an HLA-DRB3*0202 molecule, an HLA-DRB4*0101 molecule, an HLA-DPB1*0201 molecule or an HLA-DPB1*0301 molecule, and the like.

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Haruo Sugiyama
Togawa Shinji
Masayoshi Sato
Ryusei Kitamoto
Yoshihiro Goto

JP2012537718A

May 24, 2017

October 04, 2011

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Cancer Immunology Institute Co., Ltd.
Otsuka Pharmaceutical Co., Ltd.

C12N5/0783; A61K31/711; A61K35/12; A61K35/76; A61K38/00; A61K39/00; A61K48/00; A61P35/00; C07K14/82; C07K16/32; C12N5/071; C12Q1/02; A61K35/17

WO2005045027A1	2005-05-19
WO2008105462A1	2008-09-04

JPN6015039093; Ｃｌｉｎｉｃａｌ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ ｖｏｌ．　１３，　ｎｏ．　１５, 2007, ｐａｇｅｓ　４５４７　-　４５５５
JPN6015039095; ＨＥＭＡＴＯＬＯＧＹ　ＪＯＵＲＮＡＬ ｖｏｌ．　４，　ｎｏ．　１, 2003, ｐａｇｅｓ　５７　-　６６
JPN6015039096; Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ ｖｏｌ．　６８, 2008, ｐａｇｅｓ　６３５０　-　６３５９
JPN6015039098; ＭＩＣＲＯＢＩＯＬ．　ＩＭＭＵＮＯＬ． ｖｏｌ．　５２, 2008, ｐａｇｅｓ　５９１　-　６００

Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita

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