Title:
The adenovirus company virus billion for the transgenics to a neural cell
Document Type and Number:
Japanese Patent JP5907579
Kind Code:
B2
Abstract:
The present invention provides a means for transferring a therapeutic gene of interest into a nervous system cell by a highly-efficient and simpler means. More specifically, the present invention provides a recombinant vector that uses an adeno-associated virus (AAV), a method for manufacturing the recombinant vector, and a method for using the recombinant vector. More specifically, recombinant adeno-associated virus virions, which are capable of passing through the brain-brain barrier, for transferring a therapeutic genes of interest into a nervous system cell in a highly-efficient manner, a drug composition containing the recombinant adeno-associated virus virions, a method for manufacturing the recombinant adeno-associated virus virions, and a kit or the like are provided.
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Inventors:
Shinichi Muramatsu
Application Number:
JP2014215618A
Publication Date:
April 26, 2016
Filing Date:
October 22, 2014
Export Citation:
Assignee:
Jichi Medical School
International Classes:
C12N15/09; A61K31/7105; A61K31/713; A61K35/76; A61K38/22; A61K38/43; A61K39/395; A61K45/00; A61K48/00; A61P25/28; C07K14/075; C12N7/00
Domestic Patent References:
| JP2007524386A | ||||
| JP2002529098A | ||||
| JP2007507223A |
Other References:
筋萎縮性側索硬化症の病態に基づく画期的治療法の開発 平成21年度 総括研究報告書,2010年 3月,p.30-31
GRAY, SJ., et al.,Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromis,Molecular Therapy,2010年 3月,Vol.18, No.3,p.570-578
GRAY, SJ., et al.,Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromis,Molecular Therapy,2010年 3月,Vol.18, No.3,p.570-578
Attorney, Agent or Firm:
Hiroshi Kobayashi
Yasuhito Suzuki
Yasuhito Suzuki