The amino acid derivative functional-group-ized at the n-end which can form a medicine intension minute ball

Japanese Patent JP6151707

B2

Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as "APPLs". Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:wherein m, n, p, R', R¹, R², R³, R⁴, R⁵, R⁸, Z, W, Y, and Z are as defined herein.

Eijo Don
Kevin Thomas Love
Robert Es Langer
Daniel Griffith Anderson
Derai Chen
E Chen
Arturo Jose Vegas
Akinrei Arabi
Yun Long Jean

JP2014539071A

June 21, 2017

October 26, 2012

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MASSACHUSETTS INSTITUTE OF TECHNOLOGY

C07D207/16; A61K9/10; A61K9/127; A61K31/713; A61K47/18; A61K47/22; A61K47/42; A61K47/50; C07D209/20; C07D233/64; C07D241/08; C07D265/32; C07D403/06; C07D413/06; C07D487/04; C07D498/04; C09K23/22; C09K23/28; C09K23/30; C09K23/32

JP2009544600A
JP2006515574A

WO2011012746A1
WO2010078373A1
US5976569
WO2010114789A1

J. Am. Chem. Soc.,1956年,78(11),2626-2631
J. Org. Chem.,2002年,67,1820-1826
Molecular Pharmaceutics,2008年,5(2),294-315

Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai

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