Title:
β-アミノ酸ニトリル誘導体
Document Type and Number:
Japanese Patent JP3872427
Kind Code:
B2
Abstract:
The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
Inventors:
Gabriel, Tobias
Pech, michael
Rodriguez Sarmiento, Rosa Maria
Pech, michael
Rodriguez Sarmiento, Rosa Maria
Application Number:
JP2002510429A
Publication Date:
January 24, 2007
Filing Date:
June 08, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C255/44; A61K31/277; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/42; A61K31/4245; A61K31/498; A61P7/00; A61P9/00; A61P9/08; A61P9/10; A61P13/12; A61P19/02; A61P19/10; A61P33/06; A61P35/00; A61P37/02; C07C253/30; C07C255/29; C07C255/31; C07C269/06; C07C271/24; C07C271/36; C07C271/56; C07C303/40; C07C311/07; C07C311/13; C07C311/20; C07C311/46; C07C319/20; C07C323/52; C07C323/60; C07D241/44; C07D261/18; C07D271/12; C07D307/85; C07D317/60; C07D333/16; C07D333/32; C07D333/40
Foreign References:
| WO1998003540A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda
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