Title:
アミノピリミジン化合物
Document Type and Number:
Japanese Patent JP7447098
Kind Code:
B2
Abstract:
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like.The present invention relates to a compound represented by the formula (I):wherein each symbol is as defined in the specification, or a salt thereof.
Inventors:
Nobuyuki Matsunaga
Yasushi Miyamoto
Junya Shirai
Takashi Nakahata
Zensuke Shiokawa
Tomohiro Ohkawa
Akihito Shibuya
Malcolm McCos
Yasushi Miyamoto
Junya Shirai
Takashi Nakahata
Zensuke Shiokawa
Tomohiro Ohkawa
Akihito Shibuya
Malcolm McCos
Application Number:
JP2021516790A
Publication Date:
March 11, 2024
Filing Date:
September 24, 2019
Export Citation:
Assignee:
Cardurion Pharmaceuticals, Inc.
International Classes:
C07D401/14; A61K31/5377; A61K31/5386; A61P9/00; A61P9/04; A61P9/06; A61P43/00; C07D403/14; C07D405/14; C07D413/14; C07D417/14; C07D498/08
Domestic Patent References:
| JP2018523672A | ||||
| JP2017504631A | ||||
| JP2013516447A |
Other References:
Frontiers in Pharmacology,2014年,Vol. 5,pp. 1-10
Bioorganic & Medicinal Chemistry Letters,2008年,Vol. 18,pp. 2404-2408
Bioorganic & Medicinal Chemistry Letters,2008年,Vol. 18,pp. 2404-2408
Attorney, Agent or Firm:
Norito Yamao
Go Sato
Go Sato