Title:
An antibody and its use
Document Type and Number:
Japanese Patent JP6128535
Kind Code:
B2
Abstract:
An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid ² fibrils or monomeric amyloid ²-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid ² fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid ²-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
Inventors:
Minako Hoshi
Michio Sato
Shoji Ieno
Koji Naito
Satoshi Barie
Munehiro Noda
Horii Hajime
Michio Sato
Shoji Ieno
Koji Naito
Satoshi Barie
Munehiro Noda
Horii Hajime
Application Number:
JP2015106830A
Publication Date:
May 17, 2017
Filing Date:
May 26, 2015
Export Citation:
Assignee:
tao Health Life Pharma Co., Ltd.
International Classes:
C07K16/18; A61K39/395; A61P25/28; C07K16/46; C12N5/16; C12N15/02; C12N15/09; C12P21/08; G01N33/15; G01N33/50
Domestic Patent References:
| JP2001247600A | ||||
| JP2002105099A |
Foreign References:
| WO2006016644A1 |
Other References:
蛋白質 核酸 酵素,2004年 5月,Vol.49, No.7,pp.1098-1100
Proc. Natl. Acad. Sci. USA,2003年,Vol.100, No.11,pp.6370-6375
化学と工業,2004年 5月,Vol.57, No.5,pp.519-521
Biochem. Biophys. Res. Commun.,2004年,Vol.319,pp.733-737
Biochem. Biophys. Res. Commun.,2004年,Vol.325, No.2,pp.387-387
Proc. Natl. Acad. Sci. USA,2003年,Vol.100, No.11,pp.6370-6375
化学と工業,2004年 5月,Vol.57, No.5,pp.519-521
Biochem. Biophys. Res. Commun.,2004年,Vol.319,pp.733-737
Biochem. Biophys. Res. Commun.,2004年,Vol.325, No.2,pp.387-387
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners
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