Antibodies capable of binding coagulation factor XI and / or its activated form, factor XIA, and their uses

Title:

Antibodies capable of binding coagulation factor XI and / or its activated form, factor XIA, and their uses

Document Type and Number:

Japanese Patent JP6348900

Kind Code:

B2

Abstract:

The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.

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Inventors:

Birmen, Andreas
Citrus burger, Yulia
Frank, Dates Tomer
Schutlerat, Michael
Buch Miular, Anya
Grudinska-Gobel, Joanna
Huynern, Ricarda
Schierhua, Martina
Gerdes, Christoph
Yoritsusen, Hannah
Itakura, Asako
Wye Raeung, Filberta
Tatsuker, Eritsk

Application Number:

JP2015510818A

Publication Date:

June 27, 2018

Filing Date:

May 08, 2013

Export Citation:

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Assignee:

Bayer Intellectual Property GmbH

International Classes:

C12N15/09; C07K16/36; C12P21/08

Foreign References:

WO2009154461A1
WO2010080623A1

Other References:

THROMBOSIS AND HEMATOSTASIS, 2010, Vol.116, p.3981-3989
Blood, 2011, Vol.118, No.21, p.530-531, BIOSIS[online], BIOSIS Accesion No.2012:218456
Blood, 2010, Vol.116, No.21, Abstract Number:820, EMBASE[online], EMBASE Accesion No.0050758439
Blood, 2007, Vol.110, No.11, Part 1, p.235A, BIOSIS[online], BIOSIS Accesion No.2008:215994
The Journal of Biological Chemistry, 1985, Vol.260, p.10714-10719
Biochemistry, 1986, Vol.25, p.2417-2424

Attorney, Agent or Firm:

Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama

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