The antibody which recognizes a tumor generating cell, antigens, and those use

Title:

The antibody which recognizes a tumor generating cell, antigens, and those use

Document Type and Number:

Japanese Patent JP6084170

Kind Code:

B2

Abstract:

Disclosed is a method for searching, identifying, or validating a marker CACNA2D1 of tumor-initiating cells. The method comprises a step of immunizing an animal using HEP-12 cells originating from a recurrent tumor and rich in originating cells. Also disclosed is a monoclonal antibody specially recognizing CACNA2D 1 or antigen-binding fragments thereof, and the use thereof for treating or preventing tumors or diseases or conditions related to CACNA2D1.

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Inventors:

Zhang Zhen
Zhao
Royal people
Han Hai eruption
Shin Treasure

Application Number:

JP2013553769A

Publication Date:

February 22, 2017

Filing Date:

February 22, 2012

Export Citation:

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Assignee:

Beijing City Tumor Control Institute

International Classes:

C07K16/30; A61K31/7088; A61K39/395; A61P35/00; C12N5/20; C12N15/09; C12P21/08

Domestic Patent References:

JP2010536852A
JP2006524049A

Other References:

Neuroscience,2008年,Vol.155,p.510-521

Attorney, Agent or Firm:

Patent Business Corporation Saegusa International Patent Office

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