Title:
抗線維化化合物
Document Type and Number:
Japanese Patent JP7185631
Kind Code:
B2
Abstract:
Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein.
Inventors:
Mirror, thomas
Papio Anou, Nikolaos
Papio Anou, Nikolaos
Application Number:
JP2019542524A
Publication Date:
December 07, 2022
Filing Date:
January 31, 2018
Export Citation:
Assignee:
Serta Therapeutics Proprietary Limited
International Classes:
C07C235/38; A61K31/165; A61K31/167; A61K31/18; A61K31/277; A61K31/337; A61K31/341; A61K31/397; A61K31/40; A61K31/4035; A61K31/41; A61K31/415; A61K31/416; A61K31/4164; A61K31/417; A61K31/4196; A61K31/42; A61K31/4245; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4465; A61K31/4468; A61K31/47; A61K31/495; A61K31/498; A61K31/5375; A61K31/538; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P29/00; A61P43/00; C07C237/20; C07C237/32; C07C237/34; C07C255/60; C07C311/46; C07D205/04; C07D207/12; C07D209/46; C07D211/22; C07D211/26; C07D211/46; C07D211/58; C07D211/70; C07D213/30; C07D213/40; C07D213/75; C07D215/08; C07D215/22; C07D215/50; C07D231/12; C07D231/40; C07D231/56; C07D233/64; C07D241/42; C07D249/08; C07D257/04; C07D257/06; C07D261/08; C07D265/36; C07D271/06; C07D271/07; C07D271/10; C07D295/088; C07D295/13; C07D295/155; C07D305/06; C07D305/08; C07D307/14; C07D401/10; C07D401/12; C07D413/12
Domestic Patent References:
| JP2009541363A | ||||
| JP2008520587A | ||||
| JP2012506852A |
Foreign References:
| WO2010144959A1 | ||||
| US20080103204 | ||||
| US20090042987 | ||||
| WO2006087393A2 |
Other References:
J. Med. Chem. ,2009年,52,2465-2481
J. Med. Chem.,2014年,57,5333-5347
European Journal of Medicinal Chemistry,2010年,45,2638-2643
Bioorg. Med. Chem.,2005年,13,1791-1797
J. Med. Chem.,2014年,57,5333-5347
European Journal of Medicinal Chemistry,2010年,45,2638-2643
Bioorg. Med. Chem.,2005年,13,1791-1797
Attorney, Agent or Firm:
Shinsuke Umeda
Yuko Matsutoya
Yu Morita
Chisuke Konno
Nobuto Oki
Yuko Matsutoya
Yu Morita
Chisuke Konno
Nobuto Oki