Title:
ANTIGEN BINDING MOLECULES THAT ACCELERATE DISAPPEARANCE OF ANTIGENS
Document Type and Number:
Japanese Patent JP2017114882
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an antigen binding molecule, a pharmaceutical composition comprising the antigen binding molecule and a production method thereof, where the binding molecule has such functions that when it binds to an antigen, it enhances uptake of the antigen into a cell, it can bind a larger number of antigen per molecule, it has improved pharmacokinetics, and it accelerates intracellular dissociation of the antigen to which it has bound outside the cell, it is released in a free state from the cell, thereby reducing the total or free antigen concentration in the serum.SOLUTION: A pharmaceutical composition comprises an antigen binding molecule comprising an antigen binding domain and an Fcγ receptor binding domain, where the antigen binding domain has a binding activity to a human FcRn under acidic pH conditions and whose antigen binding activity changes according to the ionic concentration, and the Fcγ receptor binding domain has a higher Fcγ receptor binding activity under neutral pH conditions, compared with the Fcγ receptor binding domain of a naturally occurring human IgG Fc region in which the sugar chain at position 297 by EU numbering is a fucose-containing sugar chain.SELECTED DRAWING: None
Inventors:
IGAWA TOMOYUKI
MAEDA ATSUHIKO
HARATANI KENTA
IWAYAGI YUKI
TACHIBANA TATSUHIKO
MAEDA ATSUHIKO
HARATANI KENTA
IWAYAGI YUKI
TACHIBANA TATSUHIKO
Application Number:
JP2017022949A
Publication Date:
June 29, 2017
Filing Date:
February 10, 2017
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
A61K39/395; A61P29/00; A61P35/00; A61P37/02; C12P21/02
Domestic Patent References:
| JP2008511292A | 2008-04-17 |
Foreign References:
| WO2009125825A1 | 2009-10-15 | |||
| WO2010107109A1 | 2010-09-23 |
Other References:
ZALEVSKY,J. ET AL., NATURE BIOTECHNOL., vol. 28, no. 2, JPN6017002790, February 2010 (2010-02-01), pages 157 - 159, ISSN: 0003681682
IGAWA,T. ET AL., NATURE BIOTECHNOL., vol. 28, no. 11, JPN6017002792, November 2010 (2010-11-01), pages 1203 - 1207, ISSN: 0003681683
IGAWA,T. ET AL., NATURE BIOTECHNOL., vol. 28, no. 11, JPN6017002792, November 2010 (2010-11-01), pages 1203 - 1207, ISSN: 0003681683
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto