Title:
強く結合した塩基で修飾されたオリゴヌクレオチドと人工ヌクレアーゼを組み合わせたアンチセンス作用物質
Document Type and Number:
Japanese Patent JP2009535383
Kind Code:
A
Abstract:
The present invention provides compounds having a chelating moiety and an oligonucleotide sequence wherein the oligonucleotide includes one or more modified nucleobases, such as hydroxynucleobases. The disclosed compounds are suitable for antisense therapy. The chelating moiety can be complexed to an ion of a lanthanide metal. These compounds are efficient translation inhibitors of nucleic acids and have increased binding affinity for target nucleic acids. The invention also includes compositions and methods of using these compositions as antisense therapy.
Inventors:
Carrelson, matty
Salma, Malt
Pilves, Méchs
Salma, Malt
Pilves, Méchs
Application Number:
JP2009508407A
Publication Date:
October 01, 2009
Filing Date:
April 26, 2007
Export Citation:
Assignee:
Baltic technologic development, limited
International Classes:
C07H21/04; A61K9/127; A61K31/7115; A61K31/7135; A61P31/00; A61P31/10; A61P31/12; A61P35/00; C12N15/09; C12N15/11
Domestic Patent References:
| JPH08511532A | 1996-12-03 | |||
| JPH11506452A | 1999-06-08 | |||
| JPH10508581A | 1998-08-25 | |||
| JPH10503182A | 1998-03-24 | |||
| JP2000516631A | 2000-12-12 | |||
| JP2005523235A | 2005-08-04 |
Foreign References:
| WO2005042558A1 | 2005-05-12 | |||
| WO2005042030A1 | 2005-05-12 | |||
| US5272056A | 1993-12-21 |
Other References:
JPN6012052896; Ｃｈｅｍｉｃａｌ Ｒｅｖｉｅｗｓ ９０, 1990, ５４３-５８４
JPN6012052897; Ａｃｃ． Ｃｈｅｍ． Ｒｅｓ． ２８, 1995, ３６６-３７４
JPN6012052898; Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ． １０８, 2001, ６４１-６４４
JPN6012052899; Ｆｒｅｅ Ｒａｄｉｃａｌ Ｂｉｏｌｏｇｙ ＆ Ｍｅｄｉｃｉｎｅ ３３, 2002, １-１４
JPN6012052900; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ９６, 1999, ４５００-４５０５
JPN6012052901; Ｔｅｔｒａｈｅｄｒｏｎ ５７, 2001, ６７２７-６７３２
JPN6012052902; Ｅｕｒ． Ｊ． Ｏｒｇ． Ｃｈｅｍ． , 2001, ２０５-２０９
JPN6012052903; Ｊ． Ｍｏｌｅｃｕｌａｒ Ｃａｔａｌｙｓｉｓ ８４, 1993, Ｌ２１-Ｌ２５
JPN6012052904; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｆａｃｕｌｔｙ ｏｆ Ｅｎｇｉｎｅｅｒｉｎｇ， ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｔｏｋｙｏ （Ｂ） ４２, 1993, １４３-１５４
JPN6012052905; Ｊ． Ｌａｂｅｌ． Ｃｏｍｐｄ． Ｒａｄｉｏｐｈａｒｍ． ４６, 2003, １７５-１８６
JPN6012052906; Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ １８, 1999, ８８１-８８２
JPN6012052907; Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ １７, 1998, ９５７-９６８
JPN6012052908; Ｂｕｌｌ． Ｋｏｒｅａｎ Ｃｈｅｍ． Ｓｏｃ． ２０, 1999, ９１７-９２０
JPN6012052909; Ｔｅｔｒａｈｅｄｒｏｎ ５１, 1995, １４５９-１４７０
JPN6012052910; Ｔｅｔｒａｈｅｄｒｏｎ ５１, 1995, ７８５７-７８６６
JPN6012052911; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ４２, 1999, ２２９-２４１
JPN6012052912; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ８, 1998, １３１７-１３２０
JPN6012052913; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍ． １１, 2000, ６２７-６３６
JPN6012052914; Ｊ． Ｌａｂｅｌ． Ｃｏｍｐｄ． Ｒａｄｉｏｐｈａｒｍ． ４３, 2000, ８３７-８４８
JPN6012052897; Ａｃｃ． Ｃｈｅｍ． Ｒｅｓ． ２８, 1995, ３６６-３７４
JPN6012052898; Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ． １０８, 2001, ６４１-６４４
JPN6012052899; Ｆｒｅｅ Ｒａｄｉｃａｌ Ｂｉｏｌｏｇｙ ＆ Ｍｅｄｉｃｉｎｅ ３３, 2002, １-１４
JPN6012052900; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ９６, 1999, ４５００-４５０５
JPN6012052901; Ｔｅｔｒａｈｅｄｒｏｎ ５７, 2001, ６７２７-６７３２
JPN6012052902; Ｅｕｒ． Ｊ． Ｏｒｇ． Ｃｈｅｍ． , 2001, ２０５-２０９
JPN6012052903; Ｊ． Ｍｏｌｅｃｕｌａｒ Ｃａｔａｌｙｓｉｓ ８４, 1993, Ｌ２１-Ｌ２５
JPN6012052904; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｆａｃｕｌｔｙ ｏｆ Ｅｎｇｉｎｅｅｒｉｎｇ， ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｔｏｋｙｏ （Ｂ） ４２, 1993, １４３-１５４
JPN6012052905; Ｊ． Ｌａｂｅｌ． Ｃｏｍｐｄ． Ｒａｄｉｏｐｈａｒｍ． ４６, 2003, １７５-１８６
JPN6012052906; Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ １８, 1999, ８８１-８８２
JPN6012052907; Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ １７, 1998, ９５７-９６８
JPN6012052908; Ｂｕｌｌ． Ｋｏｒｅａｎ Ｃｈｅｍ． Ｓｏｃ． ２０, 1999, ９１７-９２０
JPN6012052909; Ｔｅｔｒａｈｅｄｒｏｎ ５１, 1995, １４５９-１４７０
JPN6012052910; Ｔｅｔｒａｈｅｄｒｏｎ ５１, 1995, ７８５７-７８６６
JPN6012052911; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ４２, 1999, ２２９-２４１
JPN6012052912; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ８, 1998, １３１７-１３２０
JPN6012052913; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍ． １１, 2000, ６２７-６３６
JPN6012052914; Ｊ． Ｌａｂｅｌ． Ｃｏｍｐｄ． Ｒａｄｉｏｐｈａｒｍ． ４３, 2000, ８３７-８４８
Attorney, Agent or Firm:
Masao Okabe
Nobuaki Kato
Okabe
Shinichi Usui
Ikuo Fujino
Takao Ochi
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Honda Aki
Nobuaki Kato
Okabe
Shinichi Usui
Ikuo Fujino
Takao Ochi
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Honda Aki