Title:
バックボーン環化ペプチド類似体のライブラリー
Document Type and Number:
Japanese Patent JPH11500741
Kind Code:
A
Abstract:
Novel backbone-cyclized BPI peptide analogs and methods of making the same by the use of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N-functionalized amino acids constructed to include a spacer and a terminal functional group. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. A plurality of these Nalphaomega-functionalized amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis.
Inventors:
ギロン，チャイム
ホーニク，ヴェレド
ホーニク，ヴェレド
Application Number:
JP51104497A
Publication Date:
January 19, 1999
Filing Date:
August 28, 1996
Export Citation:
Assignee:
イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム
ペプター，リミテッド
ペプター，リミテッド
International Classes:
G01N33/566; C07K1/04; C07K5/00; C07K7/22; C07K7/56; C07K14/00; C07K14/655; C07K17/02; G01R31/3185; A61K38/00; (IPC1-7): C07K5/00; C07K17/02; G01N33/566
Attorney, Agent or Firm:
平木 祐輔 （外２名）