Title:
D-ホモエストラ-4,9-ジエン-3-オンの11β-ベンズアルドキシム誘導体類
Document Type and Number:
Japanese Patent JP2009518347
Kind Code:
A
Abstract:
The present patent application relates to 11beta-benzaldoxime derivatives of D-homooestra-4,9-dien-3-ones of formula I: wherein R1 is a hydrogen atom or a C1-C6-alkyl, C1-C6-acyl, C1-C4-alkoxycarbonyl, C1-C4-alkylthiocarbonyl, C1-C6-alkylaminocarbonyl or arylaminocarbonyl group; and R2 is a hydrogen atom or a C1-C6-alkyl or C1-C6-acyl group. Compounds of formula I bind more strongly to the glucocorticoid receptor than to the progesterone receptor and are effective antiglucocorticoids. According to the invention, they are suitable for the treatment and/or prevention of symptoms and/or diseases that are attributable to an androgen deficiency induced by glucocorticoids, especially cortisol.
Inventors:
Link, sufen
Schwert, Gerd
Sobek, rotor
Schwert, Gerd
Sobek, rotor
Application Number:
JP2008543750A
Publication Date:
May 07, 2009
Filing Date:
December 06, 2006
Export Citation:
Assignee:
Bayer Schering Pharma Aktiengesellschaft
International Classes:
C07J63/00; A61K31/565; A61P5/26; A61P5/46; A61P15/08; A61P15/10; A61P43/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima