Title:
p38キナーゼ阻害剤として有用な二環性複素環化合物
Document Type and Number:
Japanese Patent JP2009504658
Kind Code:
A
Abstract:
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
Inventors:
Chiang, Men-Shin
Doherty, The Aims Bee
Robert Tinebore
Natarajyan, Swaminathan Earl
Lee, Chiang
Saho, Sumiya Pee
Doherty, The Aims Bee
Robert Tinebore
Natarajyan, Swaminathan Earl
Lee, Chiang
Saho, Sumiya Pee
Application Number:
JP2008526149A
Publication Date:
February 05, 2009
Filing Date:
August 08, 2006
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D455/02; A61K31/4375; A61K31/4545; A61K31/4985; A61K31/506; A61P1/04; A61P11/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P33/06; A61P35/00; A61P37/06; A61P43/00; C07D471/04
Foreign References:
| WO1998027098A1 | 1998-06-25 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura