５ＨＴ１Ｄアンタゴニストとしてのビフェニル誘導体

Japanese Patent JPH09510718

A

Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R<1> is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxy C1-6alkoxy, acyl, nitro, trifluoromethyl, cyano, SR<9>, SOR<9>, SO2R<9>, SO2NR<10>R<11>, CO2R<10>, CONR<10>R<11>, CO2NR<10>R<11>, CONR<10>(CH2)pCO2R<11>, (CH2)pNR<10>R<11>, (CH2)pCONR<10>R<11>, (CH2)pCO2C1-6alkyl, NR<10>R<11>, NR<10>CO2R<11>, NR<10>CONR<10>R<11>, CR<10>=NOR<11>, CNR<10>=NOR<11>, where R<10> and R<11> are independently hydrogen or C1-6alkyl and p is 1 to 3; R<2> and R<3> are independently hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-6alkoxy, acyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R<10>, CONR<10>R<11>, NR<10>R<11> where R<10> and R<11> are independently hydrogen or C1-6alkyl; R<4> and R<5> are independently hydrogen or C1-6alkyl; R<6> is hydrogen, halogen, hydroxy, C1-6alkyl or C1-6alkoxy; R<7> and R<8> are independently hydrogen, C1-6alkyl, aralkyl, or together with the nitrogen atom to which they are attached form an optionally substituted 5-7-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, nitrogen or sulphur; A is CONH or NHCO; B is oxygen, S(O)p where p is 0, 1 or 2, or B is NR<12> where R<12 is hydrogen or C>1-6