Title:
The bispecific antibody which has a natural immunoglobulin form and which isolates easily
Document Type and Number:
Japanese Patent JP6247673
Kind Code:
B2
Abstract:
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.
Inventors:
Samuel Davis
Eric Smith
Douglas mcdonalds
Kara Lewis Olson
Eric Smith
Douglas mcdonalds
Kara Lewis Olson
Application Number:
JP2015187704A
Publication Date:
December 13, 2017
Filing Date:
September 25, 2015
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
C07K16/46; C07K1/22; C07K16/18; C12N15/09; C12P21/08
Domestic Patent References:
| JP5816170B2 | ||||
| JP9506001A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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