c-Met MODULATOR AND ITS USE

Title:

c-Met MODULATOR AND ITS USE

Document Type and Number:

Japanese Patent JP2017160270

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a compound for modulating protein kinase enzymatic activity.SOLUTION: Provided is a compound for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, provided are quinazoline and quinoline inhibiting, regulating and/or modulating the signal transduction passage of a kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4 related to the changes in cellular activities as mentioned above, a composition containing these compound and a method for using them for treating kinase dependent diseases and conditions. Also provided is a method for producing the above compound, and a method for producing the composition containing these compound.SELECTED DRAWING: None

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Inventors:

BANNEN LYNNE CANNE
CHAN DIVA SZE-MING
CHEN JEFF
DALRYMPLE LISA ESTHER
FORSYTH TIMOTHY PATRICK
HUYNH TAI PHAT
JAMMALAMADAKA VASU
KHOURY RICHARD GEORGE
LEAHY JAMES WILLIAM
MAC MORRISON B
MANN GRACE
MANN LARRY W
NUSS JOHN M
PARKS JASON JEVIOUS
TAKEUCHI CRAIG STACY
WANG YONG
ZHU WEI

Application Number:

JP2017123131A

Publication Date:

September 14, 2017

Filing Date:

June 23, 2017

Export Citation:

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Assignee:

EXELIXIS INC

International Classes:

C07D215/22; A61K31/47; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/517; A61K31/535; A61K31/5377; A61P3/10; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D215/16; C07D215/20; C07D215/233; C07D215/36; C07D215/38; C07D239/88; C07D401/12; C07D401/14; C07D405/14; C07D413/00; C07D413/12; C07D413/14; C07D417/14; A61K

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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