Title:
Cancer markers and their uses
Document Type and Number:
Japanese Patent JP6341859
Kind Code:
B2
Abstract:
The present invention provides a novel cancer marker for testing a morbidity risk of a cancer. The cancer marker according to the present invention is a prorenin receptor. A test method for testing a morbidity risk of a cancer according to the present invention includes measuring a prorenin receptor expression in a biological specimen obtained from a subject and further includes, for example, a step of comparing a prorenin receptor expression level in the biological specimen obtained from the subject with a reference value to test the morbidity risk of the cancer in the subject. The reference value is a prorenin receptor expression level in a biological specimen obtained from a healthy subject or a cancer patient. When the expression level in the subject is higher than that in the healthy subject or identical to or higher than that in the cancer patient, it can be evaluated that the subject has the mobility risk of the cancer.
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Inventors:
Nishiyama Shigeru
Fumiaki Suzuki
Fumiaki Suzuki
Application Number:
JP2014535548A
Publication Date:
June 13, 2018
Filing Date:
September 10, 2013
Export Citation:
Assignee:
National University Corporation Kagawa University
International Classes:
C12Q1/68; A61K39/395; A61P35/00; C07K14/705; G01N33/15; G01N33/50; G01N33/574
Domestic Patent References:
| JP2008182905A |
Other References:
NGUYEN, Genevieve, Renin, (pro)renin and receptor: an update., Clinical science, 2011, Vol.120, No.5, p. 169-178
NGUYEN, Genevieve, Renin and prorenin receptor in hypertension: what's new?, 2011, Vol.13, No.1, p. 79-85
市原淳弘, (プロ)レニン受容体, SRL宝函, 2012-07, Vol.33, No.2, pages 4-11
大場浩史、外7名, 乳癌における(プロ)レニン受容体発現の検討, 日本分子生物学会年会プログラム・要旨集(web),2011年,Vol. 34,2P-0747
LUCERO, Olivia M., et al.,A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers,Curent oncology reports, 2010, Vol. 12, No. 5, p. 314-318
NABI, AHM Nurun, et al.,(Pro)renin receptor and prorenin: their plausible sites of interaction.,Frontiers in biosciences, 2012, Vol. 17, p. 389-395
NGUYEN, Genevieve, Renin and prorenin receptor in hypertension: what's new?, 2011, Vol.13, No.1, p. 79-85
市原淳弘, (プロ)レニン受容体, SRL宝函, 2012-07, Vol.33, No.2, pages 4-11
大場浩史、外7名, 乳癌における(プロ)レニン受容体発現の検討, 日本分子生物学会年会プログラム・要旨集(web),2011年,Vol. 34,2P-0747
LUCERO, Olivia M., et al.,A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers,Curent oncology reports, 2010, Vol. 12, No. 5, p. 314-318
NABI, AHM Nurun, et al.,(Pro)renin receptor and prorenin: their plausible sites of interaction.,Frontiers in biosciences, 2012, Vol. 17, p. 389-395
Attorney, Agent or Firm:
Koichiro Tsujimaru
Yumi Nakayama
Isaji So
Kento Minamino
Yumi Nakayama
Isaji So
Kento Minamino