Carbazole carboxamide compounds useful as kinase inhibitors

Title:

Carbazole carboxamide compounds useful as kinase inhibitors

Document Type and Number:

Japanese Patent JP6353530

Kind Code:

B2

Abstract:

Disclosed are compounds of Formula (I); and salts thereof, wherein: Formula (II); Q is: R1 is —C(CH3)2OH, —NHC(=0)C(CH3)3, —N(CH3)2, or —CH2Rd; R2 is CI or —CH3; R3 is H, F, or —CH3; Ra is H or —CH3; Rb is H, F, CI, or —OCH3 Rc is H or F; and Rd is —OH, —OCH3, —NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

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Inventors:

Susung Ko
Douglas G Butt
Mira Board One Bertrand
George Budelka
Charles M Langvine
Genjie Liu
Anurag S Srivastava
Scott Hunter Watterson

Application Number:

JP2016523870A

Publication Date:

July 04, 2018

Filing Date:

June 25, 2014

Export Citation:

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Assignee:

BRISTOL-MYERS SQUIBB COMPANY

International Classes:

C07D403/10; A61K31/517; A61K31/519; A61P29/00; A61P37/02; A61P43/00; C07D471/04; C07D513/04

Domestic Patent References:

JP2012512888A

Foreign References:

WO2011159857A1

Other References:

Lou, Yan et al.,Bruton's tyrosine kinase inhibitors: Approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies,Journal of Medicinal Chemistry,2012年,vol.55 no.10,pp.4539-4550

Attorney, Agent or Firm:

Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori

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