Title:
carcinoma diagnosis based on genotype and medical treatment of ODC1
Document Type and Number:
Japanese Patent JP6083860
Kind Code:
B2
Abstract:
The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.
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Inventors:
Garner, eugene
Zel, jason
Mclaren, christine
Frank Macekens
Anton-Culver, Hoda
Thompson, Patricia, A.
Zel, jason
Mclaren, christine
Frank Macekens
Anton-Culver, Hoda
Thompson, Patricia, A.
Application Number:
JP2012511052A
Publication Date:
February 22, 2017
Filing Date:
May 14, 2010
Export Citation:
Assignee:
Arizona Board of Regents on behalf of the University of Arizona
The Regents of the University of California, A California Corporation
The Regents of the University of California, A California Corporation
International Classes:
A61K31/192; A61K31/198; A61P35/00; A61P43/00; C12N15/09; C12Q1/68
Other References:
Upal K.Basuroy et al, J.Biochem, 2006年, vol.139, No.1,p.27~33
Attorney, Agent or Firm:
Ryoichi Takaoka