Title:
間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物
Document Type and Number:
Japanese Patent JP7102397
Kind Code:
B2
Abstract:
An object of the present invention is to provide a cell population comprising mesenchymal cells having low cell aggregability, which is useful for intravenous administration of a cell preparation, and a method for producing the same, and a pharmaceutical composition comprising the cell population. The present invention provides a method for producing a cell population comprising mesenchymal stem cells, the method comprising obtaining a cell population having the following cell characteristics (the cell population satisfies the relative expression level of COL11A1 gene to the expression level of SDHA gene of 6.0 or less and the relative expression level of COL16A1 gene to the expression level of SDHA gene of 1.5 or less).
Inventors:
Keita Inao
Yuta Kida
Yuta Kida
Application Number:
JP2019511270A
Publication Date:
July 19, 2022
Filing Date:
April 03, 2018
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C12N5/0775
Domestic Patent References:
| JP2015500810A | ||||
| JP2008178403A | ||||
| JP2010538681A | ||||
| JP2010500047A |
Foreign References:
| WO2015025810A1 |
Other References:
STEINERT A. F., et al.,Mesenchymal Stem Cell Characteristics of Human Anterior Cruciate Ligament Outgrowth Cells,TISSUE ENGINEERING: Part A,2011年,Vol. 17, Nos. 9 and 10,pp. 1375-1388,Abstract、Table 1等
MOON J. H., et al.,Successful vitrification of human amnion-derived mesenchymal stem cells,Human Reproduction,2008年,Vol. 23, No. 8,pp. 1760-1770,Introduction第2段落、Materials and Methods、Fig. 4、Table III
MOON J. H., et al.,Successful vitrification of human amnion-derived mesenchymal stem cells,Human Reproduction,2008年,Vol. 23, No. 8,pp. 1760-1770,Introduction第2段落、Materials and Methods、Fig. 4、Table III
Attorney, Agent or Firm:
Hiraki International Patent Office