Title:
A classification of a DNA sample
Document Type and Number:
Japanese Patent JP6082141
Kind Code:
B2
Abstract:
The present application describes methods for accurate and cost-effective categorization of DNA samples into different types of in vitro generated DNA or different types of natural DNA such as from different tissues and/or physiological/pathological states. The invention achieves categorization by comparing "signal ratios" that are correlated to ratios of methylation levels at specific genomic loci, but does not rely on calculation of actual methylation levels at any genomic locus. Therefore the disclosed inventive method eliminates the requirement for external DNA species and controls, thereby simplifying and increasing the accuracy of the assay. The described inventive technology also enables performing the categorization of DNA together with DNA profiling in the same reaction, thereby allowing for concomitant categorization and determination of identity of the samples.
Inventors:
Wasselstrom, Adam
Frumkin, Dan
Frumkin, Dan
Application Number:
JP2016020484A
Publication Date:
February 15, 2017
Filing Date:
February 05, 2016
Export Citation:
Assignee:
NUCLEIX LTD.
International Classes:
C12Q1/68; C12Q1/44; C12Q1/48
Domestic Patent References:
| JP2007522795A |
Other References:
Epigenetics, (2006), 1, [3], p.146-152
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata
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