Title:
ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物
Document Type and Number:
Japanese Patent JP5706926
Kind Code:
B2
Abstract:
The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.
Inventors:
Paul Mar
Corolle Clair
Gautel Thierry
Corolle Clair
Gautel Thierry
Application Number:
JP2013107700A
Publication Date:
April 22, 2015
Filing Date:
May 22, 2013
Export Citation:
Assignee:
GUERBET
International Classes:
C07D475/04; A61K38/00; A61K49/00; A61K49/04; A61K51/00; C07D403/12; C07D519/00; C07J9/00; C07J63/00; C07K7/06
Domestic Patent References:
| JP2104588A | ||||
| JP10501528A | ||||
| JP2004509152A | ||||
| JP2005514444A | ||||
| JP2004537573A | ||||
| JP2004526671A | ||||
| JP5368099B2 |
Foreign References:
| WO2004112840A1 | ||||
| WO2004112839A1 |
Other References:
Eisenwiener, Klaus-Peter et al.,NODAGATOC, a New Chelator-Coupled Somatostatin Analogue Labeled with[67/68Ga] and [111In] for SPECT,,Bioconjugate Chemistry,2002年,Vol.13, No.3,p.530-541
VELIKYAN I,THE JOURNAL OF NUCLEAR MEDICINE,米国,SOCIETY OF NUCLEAR MEDICINE,2005年11月,V46 N11,P1881-1888
Schuhmacher, Jochen et al.,GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nudemice with a 68Ga-labeled bomb,Journal of Nuclear Medicine,2005年,Vol.46, No.4,p.691-669
HENZE M,THE JOURNAL OF NUCLEAR MEDICINE,米国,2001年 7月,V42 N7,P1053-1056
Froidevaux, Sylvie et al.,A gallium-labeled DOTA-α-melanocyte-stimulating hormone analog for PET imaging of melanoma metastas,Journal of Nuclear Medicine,2004年,Vol.45, No.1,p.116-123
HOFFEND J,NUCLEAR MEDICINE AND BIOLOGY,米国,ELSEVIER,2005年,V32,P287-292
Andre, Joao P. et al.,1,4,7-Triazacyclononane-1-succinic acid-4,7-diacetic acid (NODASA): a newbifunctional chelator for r,Chemical Communications,1998年,No.12,p.1301-1302
VELIKYAN I,THE JOURNAL OF NUCLEAR MEDICINE,米国,SOCIETY OF NUCLEAR MEDICINE,2005年11月,V46 N11,P1881-1888
Schuhmacher, Jochen et al.,GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nudemice with a 68Ga-labeled bomb,Journal of Nuclear Medicine,2005年,Vol.46, No.4,p.691-669
HENZE M,THE JOURNAL OF NUCLEAR MEDICINE,米国,2001年 7月,V42 N7,P1053-1056
Froidevaux, Sylvie et al.,A gallium-labeled DOTA-α-melanocyte-stimulating hormone analog for PET imaging of melanoma metastas,Journal of Nuclear Medicine,2004年,Vol.45, No.1,p.116-123
HOFFEND J,NUCLEAR MEDICINE AND BIOLOGY,米国,ELSEVIER,2005年,V32,P287-292
Andre, Joao P. et al.,1,4,7-Triazacyclononane-1-succinic acid-4,7-diacetic acid (NODASA): a newbifunctional chelator for r,Chemical Communications,1998年,No.12,p.1301-1302
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Toshi Gobe
Koichi Niimi