A compound useful as inhibitor of ATR kinase - VERTEX PHARMACEUTICALS INCORPORATED

Title:

A compound useful as inhibitor of ATR kinase

Document Type and Number:

Japanese Patent JP5972942

Kind Code:

B2

Abstract:

The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Inventors:

Jean-Damien Charlier
Steven Durant
David Kay
Michael O'Donnell
Ronald Negtel
Sam Hairy McCormick
Joanne Pinder
Anisa Nizarari Villani
Stephen Young
Hailey Marie Vinch
Thomas cleveland
Rev Tea Dee Fanning
Dennis Jay. Harley
Pramod Joshi
Urby Shess
Alina Sirina
Philip Michael Reaper

Application Number:

JP2014165380A

Publication Date:

August 17, 2016

Filing Date:

August 15, 2014

Export Citation:

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Assignee:

VERTEX PHARMACEUTICALS INCORPORATED

International Classes:

C07D241/26; C07D401/12; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D413/14; C07D417/04; C07D417/14; C07D471/04; C07D487/04; C07D487/08; C07D487/10; C07D491/113; C07D513/04

Domestic Patent References:

JP5702293B2

Foreign References:

WO2007111904A1

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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