Title:
改変型超抗原と標的探索化合物との結合体及び該結合体の使用
Document Type and Number:
Japanese Patent JP4175489
Kind Code:
B2
Abstract:
A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the peptide contains an amino acid sequence that is derived from staphylococcal enterotoxin A, binds to a Vbeta of a T cell receptor, and has a D227A mutation so that the peptide has a modified ability to bind to MHC class II antigens.
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Inventors:
Abramsen, Rasille
Bierque, Pale
Dole Sten, Michael
Katsuland, Terrier
Bierque, Pale
Dole Sten, Michael
Katsuland, Terrier
Application Number:
JP50425196A
Publication Date:
November 05, 2008
Filing Date:
June 07, 1995
Export Citation:
Assignee:
Active Biotech Activorag
International Classes:
C07K19/00; C12N15/09; A61K39/00; A61K39/395; A61K47/48; C07K14/31; C07K16/30; C07K16/32; C07K16/46; C12N15/00; C12N15/01; C12P21/02; A61K38/00; C12R1/44
Domestic Patent References:
| JP5508856A |
Foreign References:
| WO1993024136A1 |
Other References:
Infection and Immunity(1993),Vol.61,No.8,p.3175-3183
Proc.Natl.Acad.Sci.USA.(1991),Vol.88,p.9287-9291
J.Immunol.(1992),Vol.148,No.1,p.1-6
Biochem.Biophys.Res.Commun.(1993), Vol.193,p.1191-1197
Infection and Immunity(1992),Vol.60,No.12,p.5190-5196
Int.J.Cancer(1993),Vol.54,p.482-488
Proc.Natl.Acad.Sci.USA.(1991),Vol.88,p.9287-9291
J.Immunol.(1992),Vol.148,No.1,p.1-6
Biochem.Biophys.Res.Commun.(1993), Vol.193,p.1191-1197
Infection and Immunity(1992),Vol.60,No.12,p.5190-5196
Int.J.Cancer(1993),Vol.54,p.482-488
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura