Title:
A constituent for prevention of adhesion, and other barrier application
Document Type and Number:
Japanese Patent JP5976272
Kind Code:
B2
Abstract:
A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In one embodiment, the self-assembling material comprises peptides having a sequence of amino acid residues conforming to one or more of Formulas I-IV:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa + ) x Xaa neu -Xaa - ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(I)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa - ) x (Xaa neu -Xaa + ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(II)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa + -Xaa neu ) x (Xaa - -Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(III)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa - -Xaa neu ) x (Xaa +- Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(IV),
where Xaa neu represents an amino acid residue having a neutral charge; Xaa + represents an amino acid residue having a positive charge; Xaa - represents an amino acid residue having a negative charge; x and y are integers having a value of 1, 2, 3 or 4, independently; and n is an integer having a value of 1-5. In another embodiment, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
Inventors:
Ellis-Baink, Rutledge
Noci, Terence W.
Kelly, Stephen Richard
Noci, Terence W.
Kelly, Stephen Richard
Application Number:
JP2010506529A
Publication Date:
August 23, 2016
Filing Date:
April 25, 2008
Export Citation:
Assignee:
Arch Therapeutics, Incorporated
International Classes:
A61K38/00; A61P41/00; C07K5/10; C07K7/04; C07K14/00; C12N15/09
Foreign References:
| WO2006116524A2 | ||||
| WO2006014570A2 | ||||
| WO2005014615A2 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office