The constituent refined by the method for detecting a sub group with a rare cell, and the altitude of the cell - Astellas Institute for Regenerative Medicine

Title:

The constituent refined by the method for detecting a sub group with a rare cell, and the altitude of the cell

Document Type and Number:

Japanese Patent JP6184865

Kind Code:

B2

Abstract:

Methods are provided for detection of a target cell type within a cell population, and compositions are provided comprising cells and an indicator that indicates the number of cells of the target cell type in the cell population. Examples are provided in which these methods are used to detect human embryonic stem cells within a differentiated cell population with exquisite sensitivity. Differentiated cells produced from embryonic stem cells can be characterized by these methods before transplantation into a recipient, thereby providing further assurance of safety.

Inventors:

Klimanskaya, Irina
Gay, Roger Jay.

Application Number:

JP2013520901A

Publication Date:

August 23, 2017

Filing Date:

July 25, 2011

Export Citation:

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Assignee:

Astellas Institute for Regenerative Medicine

International Classes:

C12Q1/04; C12N5/071; C12N5/0735; C12N5/10; G01N1/28; G01N1/30; G01N21/17; G01N21/64; G01N33/48; G01N33/53; G01N33/533; G01N33/553

Domestic Patent References:

JP2005505746A
JP2010500878A

Foreign References:

US20050118713

Other References:

EMRE, N. et al., "A Comparative Analysis of Human Embryonic Stem Cells Cultured in a Variety of Media Conditions", 2008, pp. 1-8, Retrieved from the Internet: [retrieved on 2015.09.01]
SHERIDAN, S. D. et al., "Expansion of Human Embryonic Stem Cells by Membrane Based Co-Culture", 2007, Retrieved from the Internet: [retrieved on 2015.09.01]
Cloning Stem Cells, 2004, Vol. 6, No. 3, pp. 217-245

Attorney, Agent or Firm:

Kiyoji Kuzuwa

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