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A diagnosing method and a therapeutic method of Preeclampsia or Eclampsia
Document Type and Number:
Japanese Patent JP5973496
Kind Code:
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to SFltl - are also disclosed herein for the treatment of pre-eclampsia or eclampsia.

Calmanche, S Annance
Maynard, Sharon
Skatome, Vicas Pea
Application Number:
Publication Date:
August 23, 2016
Filing Date:
June 10, 2014
Export Citation:
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Beth Israel Deaconis Medical Center
International Classes:
A61K45/00; A61B10/00; A61K31/4422; A61K31/465; A61K31/506; A61K31/522; A61K31/7076; A61K31/7088; A61K31/713; A61K38/00; A61K38/18; A61K38/19; A61K38/22; A61K39/395; A61K48/00; A61P15/00; A61P15/08; A61P25/08; C07K14/475; C07K14/485; C07K14/71; C07K16/12; C07K16/22; C07K16/28; C12N15/02; C12N15/09; C12N15/113; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/68; G01N33/74
Other References:
VUORELA,P. et al,Amniotic fluid--soluble vascular endothelial growth factor receptor-1 in preeclampsia,Obstet Gynecol,2000年,Vol.95, No.3,p.353-7
LYALL,F. et al,Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in,Br J Obstet Gynaecol,1997年,Vol.104, No.2,p.223-8
REUVEKAMP,A. et al,Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsi,Br J Obstet Gynaecol,1999年,Vol.106, No.10,p.1019-1022
TIDWELL,S.C. et al,Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia,Am J Obstet Gynecol,2001年,Vol.184, No.6,p.1267-72
CLARK,D.E. et al.,A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation,Biology of Reproduction,1998年,vol. 59, no. 6,1540-1548
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takumi Terachi