Title:
The dynamic state of sFlt-1 as an index of urgency pregnancy-induced-hypertension Nephropathy and/or HELLP syndrome, or an end green / PlGF ratio
Document Type and Number:
Japanese Patent JP6034394
Kind Code:
B2
Abstract:
Diagnostic methods and tools relating to diagnosing whether a pregnant subject is at risk for developing preeclampsia and/or early-onset preeclampsia within a short period of time. The methods include determining the amounts of the biomarkers sFlt-1 or Endoglin and PIGF in a first and a second sample of said subject, said first sample being obtained prior to said second sample; calculating a first ratio from the amounts of sFlt-1 or Endoglin and PIGF determined in the first sample, and a second ratio from the amounts of sFlt-1 or Endoglin and PIGF determined in the second sample; and comparing the value of the first and the second ratio, whereby a subject being at risk for developing preeclampsia within a short period of time is diagnosed if the value of the second ratio is increased compared to the value of the first ratio by a factor of at least about 3.
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Inventors:
Deng, Barbara
Hunt, Martin
Hunt, Martin
Application Number:
JP2014540463A
Publication Date:
November 30, 2016
Filing Date:
November 08, 2012
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
G01N33/68; G01N33/53; G01N33/573
Domestic Patent References:
| JP2008514631A | ||||
| JP2009543066A | ||||
| JP2009516170A |
Foreign References:
| WO2008005814A2 | ||||
| US20060067937 | ||||
| US20070111326 | ||||
| US20090068683 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
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