Title:
An edible oral strip or wafer dosage forms containing ion-exchange resin for taste masking
Document Type and Number:
Japanese Patent JP6266075
Kind Code:
B2
Abstract:
An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
Inventors:
Michael Sing Chiwen Lee
Marx Krum
Marx Krum
Application Number:
JP2016218592A
Publication Date:
January 24, 2018
Filing Date:
November 09, 2016
Export Citation:
Assignee:
Ertes Roman Therapy-The Steme Age
International Classes:
A61K9/70; A23L27/00; A61K47/04; A61K47/10; A61K47/14; A61K47/18; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/44; A61K47/46; A61P29/00
Domestic Patent References:
| JP2008517935A | ||||
| JP2006515333A | ||||
| JP2009530291A | ||||
| JP2003527410A | ||||
| JP2010523581A |
Other References:
Drug Deliv Technol,2004年,Vol.4, No.2,p.52,54-57
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi