The epitope for diagnosis and medical treatment, and a transgenic plant

Title:

The epitope for diagnosis and medical treatment, and a transgenic plant

Document Type and Number:

Japanese Patent JP6139154

Kind Code:

B2

Abstract:

A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID N0:3, (ii) an epitope comprising sequence comprising: SEQ ID NO:1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO:3, which epitope is an isolated oligopeptide derived from a gliadin protein, (iii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognise the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided.

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Inventors:

Anderson, Robert, Paul
Hill, adrian, vivian, synthon
Jewel, Derek, Parry

Application Number:

JP2013018731A

Publication Date:

May 31, 2017

Filing Date:

February 01, 2013

Export Citation:

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Assignee:

Oxford University Innovation Limited

International Classes:

A01H5/00; C07K7/06; A01H5/10; A01K67/027; A61K38/00; A61K39/00; A61K45/00; A61P37/06; A61P37/08; A61P43/00; C07K7/08; C07K14/415; C07K19/00; C12N15/82; G01N33/15; G01N33/50; G01N33/53; G01N33/564

Domestic Patent References:

JP4932112B2

Other References:

Proc.Natl.Acad.Sci.USA.,vol.95(17),pp.10050-10054(1998)
Aliment.Pharmacol.Ther.,vol.13(7),pp.945-950(1999)
Bioorg.Med.Chem.,vol.8(15),pp.2039-2044(1998)

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Seiichi Urushiyama
Wataru Ueda

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