Title:
熱ショックタンパク質９０阻害剤
Document Type and Number:
Japanese Patent JP7157462
Kind Code:
B2
Abstract:
This disclosure is related to aromatic compounds of formula (I), and methods of their use in treating medical conditions associated with Heat Shock Protein-90 (HSP90), e.g., cancer. Compounds of formula (I) have the following structure:Also disclosed are pharmaceutical compositions comprising compounds of formula (I).
Inventors:
Liou, Jin-Ping
Ten, Choi Min
Bread, Siow-Ling
Ten, Choi Min
Bread, Siow-Ling
Application Number:
JP2019551970A
Publication Date:
October 20, 2022
Filing Date:
March 20, 2018
Export Citation:
Assignee:
Taipei Medical University
International Classes:
A61K31/05; C07C235/60; A61K31/085; A61K31/09; A61K31/12; A61K31/166; A61K31/167; A61K31/404; A61K31/416; A61K31/423; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61K31/47; A61K31/4706; A61K31/519; A61K31/5375; A61P35/00; A61P35/02; A61P43/00; C07C233/75; C07C233/88; C07C235/64; C07C239/16; C07C311/21; C07C311/29; C07D209/08; C07D213/74; C07D215/38; C07D215/40; C07D215/42; C07D231/56; C07D263/56; C07D265/30; C07D295/135; C07D295/192; C07D471/04; C07D487/04
Domestic Patent References:
| JP2008538750A |
Foreign References:
| WO2009066060A2 |
Other References:
HUANG, R. et al.,Virtual screening and biophysical studies lead to HSP90 inhibitors,Bioorganic & Medicinal Chemistry Letters,2017年,Vol.27, No.2,pp.277-281
CIKOTIENE, I. et al.,5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone,Bioorganic & Medicinal Chemistry Letters,2009年,Vol.19, No.4,pp.1089-1092
CIKOTIENE, I. et al.,5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone,Bioorganic & Medicinal Chemistry Letters,2009年,Vol.19, No.4,pp.1089-1092
Attorney, Agent or Firm:
Katsuhiro Ito
Shinichi Watanabe
Shinichi Watanabe