Title:
HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI
Document Type and Number:
Japanese Patent JP2018029623
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide humanized non-human animals with restricted immunoglobulin heavy chain loci.SOLUTION: Provided are mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Also provided are mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human Vgene segment, a plurality of human Dgene segments and a plurality of human Jgene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof.SELECTED DRAWING: None
Inventors:
LYNN MACDONALD
JOHN MCWHIRTER
TU NAXIN
SEAN STEVENS
KEBBEDE ANTENEH
JOHN MCWHIRTER
TU NAXIN
SEAN STEVENS
KEBBEDE ANTENEH
Application Number:
JP2017230304A
Publication Date:
March 01, 2018
Filing Date:
November 30, 2017
Export Citation:
Assignee:
REGENERON PHARMA
International Classes:
A01K67/027; C07K16/00; C12N5/10
Domestic Patent References:
| JP2007502622A | 2007-02-15 | |||
| JP2007516231A | 2007-06-21 |
Foreign References:
| WO2011004192A1 | 2011-01-13 |
Other References:
MURPHY D., "BAC-BASED MODIFICATIONS OF THE MOUSE GENOME: THE BIG AND THE BACKWARD", WELLCOME TRUST A, JPN7016002559, 3 November 2009 (2009-11-03), ISSN: 0004100445
IMMUNITY, vol. 13, JPN6016049289, 2000, pages 37 - 45, ISSN: 0004100446
CLIN. EXP. IMMUNOL., vol. 123, JPN6016049291, 2001, pages 1 - 8, ISSN: 0004100447
MOLECULAR IMMUNOLOGY, vol. 37, no. 5, JPN5014011414, 2000, pages 221 - 231, ISSN: 0004100448
IMMUNITY, vol. 13, JPN6016049289, 2000, pages 37 - 45, ISSN: 0004100446
CLIN. EXP. IMMUNOL., vol. 123, JPN6016049291, 2001, pages 1 - 8, ISSN: 0004100447
MOLECULAR IMMUNOLOGY, vol. 37, no. 5, JPN5014011414, 2000, pages 221 - 231, ISSN: 0004100448
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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