Title:
huTNFR1選択的拮抗剤
Document Type and Number:
Japanese Patent JP5534819
Kind Code:
B2
Abstract:
The present invention relates to a ligand which specifically binds to the human tumor necrosis factor type 1 receptor (huTNFR1), the ligand comprising one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in human beings and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention further relates to a nucleic acid encoding said ligand and to a pharmaceutical composition for the treatment of disorders connected to huTNFR1.
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Inventors:
Pfizzen Meier Claus
Schurich Peter
Contelman Lorant
Munkel Sabine
Schurich Peter
Contelman Lorant
Munkel Sabine
Application Number:
JP2009553952A
Publication Date:
July 02, 2014
Filing Date:
March 13, 2008
Export Citation:
Assignee:
Universitate Stuttgart
International Classes:
C07K19/00; A61K38/00; A61K48/00; A61P1/04; A61P3/00; A61P17/06; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; C07K14/47; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02
Domestic Patent References:
| JP4211392A |
Other References:
Methods, 36(2005) p.35-42
JESPERS L S,BIO/TECHNOLOGY,米国,NATURE PUBLISHING CO.,1994年 9月 1日,V12 N9,P899-903
MOOSMAYER D,THERAPEUTIC IMMUNOLOGY,1995年 2月,V2 N1,P31-40
JESPERS L S,BIO/TECHNOLOGY,米国,NATURE PUBLISHING CO.,1994年 9月 1日,V12 N9,P899-903
MOOSMAYER D,THERAPEUTIC IMMUNOLOGY,1995年 2月,V2 N1,P31-40
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office