Title:
イブプロフェン系化合物、その調製方法、使用および製剤
Document Type and Number:
Japanese Patent JP2014523911
Kind Code:
A
Abstract:
Disclosed are compounds based on ibuprofen, their preparation methods, uses and pharmaceutical preparation. The compounds have structures shown as formula (1), wherein, m, n are integers and fulfill the requirements of 0≰n≰6, 0≰m≰6, respectively. The preparation methods for the compounds based on ibuprofen are as follows: contacting and reacting 2-(4-isobutyl-phenyl) propionic acid to have contact reaction with a solution of an organic acid ester in the presence of a catalyst under substitution reaction conditions The present compounds can be used to prepare nonsteroidal anti-inflammatory drugs. The preparation can be preparation of fat emulsion, liposome, and dried emulsion and so on.
Inventors:
蘇 慶
Cold 国慶
侯 文閣
宋 Yukimitsu
陳 曦
Cold 国慶
侯 文閣
宋 Yukimitsu
陳 曦
Application Number:
JP2014520502A
Publication Date:
September 18, 2014
Filing Date:
May 23, 2012
Export Citation:
Assignee:
Kokuryuuko 宝慶隆 living thing technical limited liability Corp.
International Classes:
C07C69/612; A61K31/222; A61K47/10; A61K47/12; A61K47/24; A61K47/26; A61K47/28; A61P29/00; C07C67/10; C07B53/00; C07B61/00
Domestic Patent References:
| JP2005511556A | 2005-04-28 | |||
| JPH01211550A | 1989-08-24 | |||
| JPS6028957A | 1985-02-14 | |||
| JPS57206640A | 1982-12-18 |
Foreign References:
| WO1998040066A1 | 1998-09-17 | |||
| WO1998040078A1 | 1998-09-17 |
Attorney, Agent or Firm:
Yoshiaki Nagata
Motoaki Nagata
Eiji Ota
Hiroshi Nishimura
Motoaki Nagata
Eiji Ota
Hiroshi Nishimura