Title:
注入可能なゲル製品
Document Type and Number:
Japanese Patent JP7309716
Kind Code:
B2
Abstract:
A method of producing an injectable gel product is provided, comprising (a) cross-linking a first glycosaminoglycan (GAG) with a first crosslinking agent to produce a gel, wherein the charging ratio of crosslinking agent to disaccharide unit is below 0.15; (b) preparing particles of the gel; (c) mixing the glycosaminoglycan (GAG) gel particles with a second GAG to provide a mixture; (d) cross-linking the mixture with a second crosslinking agent to obtain cross-linking between the GAGs of the second, outer phase, thereby providing a gel having a first, inner phase of the cross-linked GAG gel particles, embedded in a gel of the second GAG outer phase; and (e) preparing injectable particles, each such particle containing a plurality of the cross-linked GAG gel particles of the first, inner phase. An injectable gel product, an aqueous composition, and a pre-filled syringe as also provided.
Inventors:
Ok Ehrlund
morgan carlson
morgan carlson
Application Number:
JP2020533777A
Publication Date:
July 18, 2023
Filing Date:
December 18, 2018
Export Citation:
Assignee:
Galderma Holding Society Anonym
International Classes:
A61K31/728; A61L27/20; A61M5/28; A61P19/02
Foreign References:
| US20170143870 | ||||
| US20120190644 | ||||
| EP2011816A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
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