Title:
虚血／再灌流障害
Document Type and Number:
Japanese Patent JP7164885
Kind Code:
B2
Abstract:
The invention provides methods of treating ischemia/reperfusion injury in a subject. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide in ischemic tissue. The invention also provides methods of treating a subject at risk of ischemia/reperfusion injury. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide. In the invention methods, in one example, a pharmaceutical composition comprises a nucleic acid encoding BAG3 polypeptide.
Inventors:
Feldman, Arthur M.
Chen, Joseph Wai.
Hariri, Kamel
Chen, Joseph Wai.
Hariri, Kamel
Application Number:
JP2019529143A
Publication Date:
November 02, 2022
Filing Date:
August 10, 2017
Export Citation:
Assignee:
Temple University of the Commonwealth System of Higher Education
International Classes:
A61K38/17; A61K45/08; A61K48/00; A61P3/06; A61P9/00; A61P9/08; A61P9/10; A61P41/00; A61P43/00
Other References:
JCI Insight, 2016.11, Vol.1, No.19, e90931
Cell Physiol Biochem, 2016.7, Vol.39, pp.491-500
J. Cell Physiol., 2014, Vol.229, No.11, pp.1697-1702
Brain Research, 2010, Vol.1349, No.19, pp.1-10
Med Sci Monit, 2016.01 Epub, Vol.22, pp.977-983
日本薬理学雑誌, 1996, Vol.108, pp.195-202
日本医科大学医学会雑誌, 2012, Vol.8, No.3, pp.216-221
Cell Physiol Biochem, 2016.7, Vol.39, pp.491-500
J. Cell Physiol., 2014, Vol.229, No.11, pp.1697-1702
Brain Research, 2010, Vol.1349, No.19, pp.1-10
Med Sci Monit, 2016.01 Epub, Vol.22, pp.977-983
日本薬理学雑誌, 1996, Vol.108, pp.195-202
日本医科大学医学会雑誌, 2012, Vol.8, No.3, pp.216-221
Attorney, Agent or Firm:
Takuro Saeki
Tadashi Nakamura Exhibition
Naoko Ushiyama
Yuko Saeki
Tadashi Nakamura Exhibition
Naoko Ushiyama
Yuko Saeki
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