Title:
mGluR4アロステリック増強剤、組成物、および神経機能不全を治療する方法
Document Type and Number:
Japanese Patent JP2013508412
Kind Code:
A
Abstract:
Pyrazole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
Inventors:
Gong, Jeff. Jeffrey
Linsley, Craig W.
Hopkins, Corey Earl.
Niswender, Colleen M.
Gogliotti, Rocco Dee.
Linsley, Craig W.
Hopkins, Corey Earl.
Niswender, Colleen M.
Gogliotti, Rocco Dee.
Application Number:
JP2012535428A
Publication Date:
March 07, 2013
Filing Date:
October 22, 2010
Export Citation:
Assignee:
VANDERBILT UNIVERSITY
International Classes:
A61K31/4439; A61K31/427; A61K31/4709; A61K31/5377; A61K45/00; A61K45/06; A61P3/00; A61P3/04; A61P3/10; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D417/12
Foreign References:
| US20080300260A1 | 2008-12-04 | |||
| WO2007058346A1 | 2007-05-24 | |||
| WO2008118758A1 | 2008-10-02 | |||
| US20080153704A1 | 2008-06-26 |
Other References:
JPN7014003140; ＥＬＺＥＩＮ， Ｅ． ｅｔ ａｌ．: 'Ｄｉｓｃｏｖｅｒｙ ｏｆ ａ ｎｏｖｅｌ Ａ２Ｂ Ａｄｅｎｏｓｉｎｅ ｒｅｃｅｐｔｏｒ ａｎｔａｇｏｎｉｓｔ ａｓ ａ ｃｌｉｎｉｃａｌ ｃａｎｄｉｄａｔｅ ｆｏｒ ｃｈｒｏｎｉｃ ｉｎｆｌａｍｍａｔ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．５１， Ｎｏ．７, 2008, ｐ．２２６７-２２７８
Attorney, Agent or Firm:
Shintaro Nogawa
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita