Title:
mTOR KINASE INHIBITOR FOR ONCOLOGICAL BEHAVIORS AND DISEASES RELATED TO mTOR/PI3K/AKT PATHWAY
Document Type and Number:
Japanese Patent JP2017014256
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an intermediate compound for providing a heteroaryl compound for treatment or prevention of inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neuropathy, diseases related to aging or cardiovascular conditions.SOLUTION: There is provided a compound represented by the formula (VI), where X is halogen, B(OR)or Sn(R), Ris H, Calkyl, cycloalkyl or the like, Ris H or Calkyl, Ris independently H or C1-3 alkyl or each Rform a cyclic boronate together with a boron atom or an atom bound to them and Ris Calkyl.SELECTED DRAWING: None
Inventors:
JAN ELSNER
ROY L HARRIS
BRANDEN LEE
DEBORAH MORTENSEN
GARRICK PACKARD
PATRICK PAPA
SOPHIE PERRIN-NINKOVIC
JENNIFER RIGGS
SABITA SANKAR
JOHN SAPIENZA
GRAZIELLA SHEVLIN
LIDA TEHRANI
XU WEIMING
JINGJING ZHAO
JASON PARNES
LOUI MADAKAMUTIL
KIMBERLY FULTZ
RAMA K NARLA
ROY L HARRIS
BRANDEN LEE
DEBORAH MORTENSEN
GARRICK PACKARD
PATRICK PAPA
SOPHIE PERRIN-NINKOVIC
JENNIFER RIGGS
SABITA SANKAR
JOHN SAPIENZA
GRAZIELLA SHEVLIN
LIDA TEHRANI
XU WEIMING
JINGJING ZHAO
JASON PARNES
LOUI MADAKAMUTIL
KIMBERLY FULTZ
RAMA K NARLA
Application Number:
JP2016159422A
Publication Date:
January 19, 2017
Filing Date:
August 16, 2016
Export Citation:
Assignee:
SIGNAL PHARM LLC
International Classes:
C07D471/14; A61K31/4985; A61K31/5377; A61K31/5383; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P21/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07D487/04; C07D487/10; C07D487/14; C07D498/14; C07D519/00
Domestic Patent References:
| JP5689420B2 | 2015-03-25 |
Foreign References:
| WO2008051493A2 | 2008-05-02 | |||
| WO2007061737A2 | 2007-05-31 | |||
| WO2006090169A1 | 2006-08-31 | |||
| WO2005097107A2 | 2005-10-20 |
Attorney, Agent or Firm:
Toru Ishikawa