Title:
A manufacturing method of 2'-trifluoromethyl group substitution aromatic ketone
Document Type and Number:
Japanese Patent JP6086163
Kind Code:
B2
Abstract:
The present invention is a method of producing a 2'-trifluoromethyl-substituted aromatic ketone comprising reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2'-trifluoromethyl-substituted aromatic ketone. The method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention enables 2'-trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2'-trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.
Inventors:
Jiro Nakatani
Tatsuhiro Nozoe
Tatsuhiro Nozoe
Application Number:
JP2015555879A
Publication Date:
March 01, 2017
Filing Date:
September 07, 2015
Export Citation:
Assignee:
Toray Fine Chemicals Co., Ltd.
International Classes:
C07C45/45; C07C49/76; C07C49/78
Domestic Patent References:
| JP2006504667A | 2006-02-09 | |||
| JP2009102264A | 2009-05-14 | |||
| JP2014065693A | 2014-04-17 | |||
| JP2011515373A | 2011-05-19 | |||
| JP2011519827A | 2011-07-14 | |||
| JP2013518919A | 2013-05-23 | |||
| JP2006504667A | 2006-02-09 | |||
| JP2016069299A | 2016-05-09 |
Foreign References:
| WO2002050009A1 | 2002-06-27 | |||
| CN101544561A | 2009-09-30 |
Other References:
JPN6016033798; ＢＥＮＨＡＩＭ，Ｃ． ｅｔ ａｌ．: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ beta-Ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ alpha-Ａｍｉｎｏ Ａｃｉｄｓ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２， Ｎｏ．９, 2010, ｐ２００８-２０１１
JPN6016033799; ＬＥＡＺＥＲ，Ｊ．Ｌ． ｅｔ ａｌ．: 'Ａｎ Ｉｍｐｒｏｖｅｄ Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ３，５-Ｂｉｓ（ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ）ａｃｅｔｏｐｈｅｎｏｎｅ ａｎｄ Ｓａｆｅｔｙ Ｃｏｎｓｉｄｅｒａｔｉｏｎｓ ｉｎ ｔｈｅ Ｐｒｅ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６８， Ｎｏ．９, 2003, ｐ３６９５-３６９８
JPN6016033800; ＭＡＪＩ，Ｍ．Ｓ． ｅｔ ａｌ．: 'Ｔｒａｎｓｉｔｉｏｎ-Ｍｅｔａｌ-Ｆｒｅｅ Ｓｏｎｏｇａｓｈｉｒａ-Ｔｙｐｅ Ｃｏｕｐｌｉｎｇ ｏｆ ｏｒｔｈｏ-Ｓｕｂｓｔｉｔｕｔｅｄ Ａｒｙｌ ａｎｄ Ａｌｋｙｎｙｌ Ｇｒｉｇｎａｒｄ Ｒｅａｇｅ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２，Ｎｏ．１７, 2010, ｐ３８７８-３８８１
JPN6016033798; ＢＥＮＨＡＩＭ，Ｃ． ｅｔ ａｌ．: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ beta-Ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ alpha-Ａｍｉｎｏ Ａｃｉｄｓ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２， Ｎｏ．９, 2010, ｐ２００８-２０１１
JPN6016033799; ＬＥＡＺＥＲ，Ｊ．Ｌ． ｅｔ ａｌ．: 'Ａｎ Ｉｍｐｒｏｖｅｄ Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ３，５-Ｂｉｓ（ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ）ａｃｅｔｏｐｈｅｎｏｎｅ ａｎｄ Ｓａｆｅｔｙ Ｃｏｎｓｉｄｅｒａｔｉｏｎｓ ｉｎ ｔｈｅ Ｐｒｅ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６８， Ｎｏ．９, 2003, ｐ３６９５-３６９８
JPN6016033800; ＭＡＪＩ，Ｍ．Ｓ． ｅｔ ａｌ．: 'Ｔｒａｎｓｉｔｉｏｎ-Ｍｅｔａｌ-Ｆｒｅｅ Ｓｏｎｏｇａｓｈｉｒａ-Ｔｙｐｅ Ｃｏｕｐｌｉｎｇ ｏｆ ｏｒｔｈｏ-Ｓｕｂｓｔｉｔｕｔｅｄ Ａｒｙｌ ａｎｄ Ａｌｋｙｎｙｌ Ｇｒｉｇｎａｒｄ Ｒｅａｇｅ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２，Ｎｏ．１７, 2010, ｐ３８７８-３８８１
JPN6016033798; ＢＥＮＨＡＩＭ，Ｃ． ｅｔ ａｌ．: 'Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ beta-Ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ alpha-Ａｍｉｎｏ Ａｃｉｄｓ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２， Ｎｏ．９, 2010, ｐ２００８-２０１１
Attorney, Agent or Firm:
Ichijo power
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