Title:
A manufacturing method of (E) -N-monoalkyl 3-oxo 3- (2-thienyl) pro pen amine, manufacturing method [for the same], and (E, Z) -N-monoalkyl 3-oxo 3- (2-thienyl) pro pen amine
Document Type and Number:
Japanese Patent JP5955281
Kind Code:
B2
Abstract:
The present invention provides a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by Formula (1);
wherein R is a C 1-4 alkyl,
the method comprising the steps of:
maintaining a solution containing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine dissolved therein at 25°C or below to deposit crystals and separating crystals having a particle diameter of 100 µm or less from the deposited crystals; and a process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine comprising the steps of:
reacting an alkali metal salt of ²-oxo-²-(2-thienyl)propanal with a monoalkylamine compound; adding a water-insoluble organic solvent to the resulting reaction mixture; adding seed crystals containing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to an organic layer obtained by conducting separation; and keeping the resulting mixture at 25°C or below.
Inventors:
Shuzo Satake
Noriyuki Hayashizaka
Ichiro Fushiya
Muneaki Tanaka
Hirokazu Kagano
Noriyuki Hayashizaka
Ichiro Fushiya
Muneaki Tanaka
Hirokazu Kagano
Application Number:
JP2013146139A
Publication Date:
July 20, 2016
Filing Date:
July 12, 2013
Export Citation:
Assignee:
Sumitomo Seika Co., Ltd.
International Classes:
C07D333/22
Domestic Patent References:
| JP2004155770A |
Other References:
Chemical Abstracts、1973年、Vol.79、第295頁、Abstract No.114803
A.Couture 外2名著、ELUDE COMPARATIVE DE LA PHOTOREACTIVITE D’ENAMIDES ET DE THIOENAMIDES AROMATIQUES TERTIAIRES、Tetrahedron、Pergamon Press Ltd.発行、1984年、Vol.40、No.10、第1835~1844頁
A.Couture 外2名著、ELUDE COMPARATIVE DE LA PHOTOREACTIVITE D’ENAMIDES ET DE THIOENAMIDES AROMATIQUES TERTIAIRES、Tetrahedron、Pergamon Press Ltd.発行、1984年、Vol.40、No.10、第1835~1844頁
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office