Title:
新規中間体を使用したボリコナゾールの製造方法
Document Type and Number:
Japanese Patent JP5553911
Kind Code:
B2
Abstract:
Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.
Inventors:
Kwong, ヒョク チョル
ノ, Mann Boss
チャ, キョン ヒ
ノ, Mann Boss
チャ, キョン ヒ
Application Number:
JP2012551915A
Publication Date:
July 23, 2014
Filing Date:
February 01, 2011
Export Citation:
Assignee:
Boss Cook Pharmaceutical Company Limited
International Classes:
C07D403/10; C07D239/34; A61K31/506; A61P31/10; C07B57/00; C07B61/00
Attorney, Agent or Firm:
Seiji Kuzuwa